The Anatolia Hotel Thessaloniki is located in Dimokratia Square in the central downtown district. The International Exhibition Center is 2 km from the hotel. The Anatolia Hotel Thessaloniki is 300 meters from the railway station. It is a 30 minute drive from the hotel to the airport.

There are 71 rooms at the Anatolia Hotel Thessaloniki. Rooms are individually decorated with marble bathrooms. Other amenities include air conditioning, LCD television screens, satellite television service, high speed Internet action, mini bar, safe boxes, and direct dial telephone.

The Anatolia Hotel Thessaloniki is a three star restaurant with a reception desk that is staffed 24 hours a day. There is a breakfast served each morning with homemade items, and there is a full service restaurant on the ground floor serving Grecian meal throughout the day. A meeting room is available for up to 60 people for business and social events. For relaxation, the hotel offers a sauna and a cocktail lounge on the first floor. Parking is available to guests of the hotel.